{"id":115,"date":"2021-10-18T18:06:10","date_gmt":"2021-10-18T09:06:10","guid":{"rendered":"https:\/\/miki-iin.net\/blog\/?p=115"},"modified":"2021-10-18T18:06:10","modified_gmt":"2021-10-18T09:06:10","slug":"%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e5%be%8c%e3%80%81%e6%8a%97%e4%bd%93%e4%be%a1%e3%81%8c%e8%91%97%e6%98%8e%e3%81%ab%e4%bd%8e%e4%b8%8b%e3%81%99%e3%82%8b%e4%ba%ba%e3%81%a8%e3%81%af","status":"publish","type":"post","link":"https:\/\/miki-iin.net\/blog\/%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e5%be%8c%e3%80%81%e6%8a%97%e4%bd%93%e4%be%a1%e3%81%8c%e8%91%97%e6%98%8e%e3%81%ab%e4%bd%8e%e4%b8%8b%e3%81%99%e3%82%8b%e4%ba%ba%e3%81%a8%e3%81%af\/","title":{"rendered":"\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001\u6297\u4f53\u4fa1\u304c\u8457\u660e\u306b\u4f4e\u4e0b\u3059\u308b\u4eba\u3068\u306f\uff1f"},"content":{"rendered":"\n<p>\u7686\u3055\u3093\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u9d3b\u6c60\u65b0\u7530\u306e\u5fc3\u7642\u5185\u79d1\u300c\u5fc3\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e09\u6728\u533b\u9662\u300d\u306e\u9662\u9577\u3001\u4e09\u6728\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e16\u9593\u7684\u306b\u3082\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u9032\u307f\u3001\u305d\u308c\u306b\u4f34\u3044\u65b0\u898f\u611f\u67d3\u60a3\u8005\u6570\u3082\u6e1b\u3063\u3066\u304d\u3066\u3001\u307e\u308b\u3067\u300c\u7d42\u606f\u3057\u3066\u304d\u3066\u3044\u308b\u300d\u3088\u3046\u306b\u611f\u3058\u307e\u3059\u306d\u3002<\/p>\n\n\n\n<p>\u30ef\u30af\u30c1\u30f3\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u63a5\u7a2e\u3057\u3066\u304d\u305f\u201c\u30ef\u30af\u30c1\u30f3\u5148\u9032\u56fd\u201d\u306e\u30a4\u30b9\u30e9\u30a8\u30eb\u3067\u306f\u3001\u4eca\u306e\u65e5\u672c\u306e\u3088\u3046\u306b\u3001\u4eca\u5e745\u6708\u304b\u30896\u6708\u306b\u304b\u3051\u3066\u611f\u67d3\u8005\u6570\u30fb\u6b7b\u8005\u6570\u304c\u3068\u3082\u306b\u307b\u307c\u30bc\u30ed\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u30016\u6708\u672b\u4ee5\u964d\u307e\u305f\u5897\u52a0\u306b\u8ee2\u3058\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure 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loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"641\" src=\"https:\/\/miki-iin.net\/blog\/wp-content\/uploads\/2021\/10\/a24d06e1a4ef467262b5771befbc7b9b-1-800x641.png\" alt=\"\" class=\"wp-image-119\" srcset=\"https:\/\/miki-iin.net\/blog\/wp-content\/uploads\/2021\/10\/a24d06e1a4ef467262b5771befbc7b9b-1-800x641.png 800w, https:\/\/miki-iin.net\/blog\/wp-content\/uploads\/2021\/10\/a24d06e1a4ef467262b5771befbc7b9b-1-300x241.png 300w, https:\/\/miki-iin.net\/blog\/wp-content\/uploads\/2021\/10\/a24d06e1a4ef467262b5771befbc7b9b-1-768x616.png 768w, https:\/\/miki-iin.net\/blog\/wp-content\/uploads\/2021\/10\/a24d06e1a4ef467262b5771befbc7b9b-1.png 1049w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" 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class=\"wp-block-embed is-type-wp-embed is-provider-\u5fc3\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e09\u6728\u533b\u9662-\u30d6\u30ed\u30b0 wp-block-embed-\u5fc3\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e09\u6728\u533b\u9662-\u30d6\u30ed\u30b0\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"mdlLMFm7uW\"><a href=\"https:\/\/miki-iin.net\/blog\/%e3%80%8c%e3%83%af%e3%82%af%e3%83%81%e3%83%b33%e5%9b%9e%e7%9b%ae%e3%83%96%e3%83%bc%e3%82%b9%e3%82%bf%e3%83%bc%e6%8e%a5%e7%a8%ae%e3%80%8d%e3%81%af%e7%9c%9f%e3%81%ab%e6%9c%89%e5%8a%b9\/\">\u300c\u30ef\u30af\u30c1\u30f33\u56de\u76ee\u201c\u30d6\u30fc\u30b9\u30bf\u30fc\u201d\u63a5\u7a2e\u300d\u306f\u771f\u306b\u6709\u52b9\u304b\uff1f<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;\u300c\u30ef\u30af\u30c1\u30f33\u56de\u76ee\u201c\u30d6\u30fc\u30b9\u30bf\u30fc\u201d\u63a5\u7a2e\u300d\u306f\u771f\u306b\u6709\u52b9\u304b\uff1f&#8221; &#8212; \u5fc3\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e09\u6728\u533b\u9662 \u30d6\u30ed\u30b0\" src=\"https:\/\/miki-iin.net\/blog\/%e3%80%8c%e3%83%af%e3%82%af%e3%83%81%e3%83%b33%e5%9b%9e%e7%9b%ae%e3%83%96%e3%83%bc%e3%82%b9%e3%82%bf%e3%83%bc%e6%8e%a5%e7%a8%ae%e3%80%8d%e3%81%af%e7%9c%9f%e3%81%ab%e6%9c%89%e5%8a%b9\/embed\/#?secret=WxNmtYaGxO#?secret=mdlLMFm7uW\" data-secret=\"mdlLMFm7uW\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" 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href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2114583\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2114583<\/a><\/p>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u306f\u3001<br>\u30fb\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\u611f\u67d3\uff08\uff1d\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u306e\u611f\u67d3\uff09\u306f20\u4f8b\u3001N\u6297\u4f53\u967d\u6027\uff08\uff1d\u904e\u53bb\u306e\u81ea\u7136\u611f\u67d3\u3092\u793a\u5506\uff09\u306f5\u4f8b\u3002<br>\u30fb\u6297\u4f53\u4fa1\u306f2\u56de\u63a5\u7a2e\u5f8c\u3001\u6700\u521d3\u30f6\u6708\u3067\u6025\u6fc0\u306b\u4f4e\u4e0b\u3059\u308b\u304c\u3001\u305d\u306e\u5f8c\u306f\u6bd4\u8f03\u7684\u7de9\u3084\u304b\u306a\u4f4e\u4e0b\u3067\u3042\u3063\u305f\u3002<br>\u30fb\u63a5\u7a2e\u3057\u30666\u30f6\u6708\u5f8c\u3001\u6297\u4f53\u4fa1\u306f\u3001\u7537\u6027\u3067\u7279\u306b\u4f4e\u304f(substantially 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